Journal article
Type of anesthesia for cancer resection surgery: No differential impact on cancer recurrence in mouse models of breast cancer
J Dubowitz, AI Ziegler, R Beare, F Jost-Brinkman, AK Walker, RD Gillis, A Chang, NC Chung, OA Martin, F Hollande, B Riedel, EK Sloan
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2023
Abstract
Background Surgery is essential for curative treatment of solid tumors. Evidence from recent retrospective clinical analyses suggests that use of propofol-based total intravenous anesthesia during cancer resection surgery is associated with improved overall survival compared to inhaled volatile anesthesia. Evaluating these findings in prospective clinical studies is required to inform definitive clinical guidelines but will take many years and requires biomarkers to monitor treatment effect. Therefore, we examined the effect of different anesthetic agents on cancer recurrence in mouse models of breast cancer with the overarching goal of evaluating plausible mechanisms that could be used as b..
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Grants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
This work was supported by the Australian and New Zealand College of Anaesthetists (17/003, JD, BR) and Perpetual Trustees (JD, BR), National Health and Medical Research Council (NHMRC) grants 1147498 (ES, FH, OM, BR), 1160191 (BR), National Breast Cancer Foundation IIRS-20-025 (ES, BR), and The David and Lorelle Skewes Foundation (ES, BR). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.